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02190148 MP BIOMEDICALS AMPICILLIN SODIUM SALT · Download MSDS (PDF) Synonyms D(-)-α-Aminobenzylpenicillin sodium salt, 6-[D(-)-a-Aminophenylacetamido]penicillanic acid
· CAS Number 69-52-3 · Molecular Formula C16H18N3NaO4S · Molecular Weight 371.39 · Beilstein Registry Number 4119211 · EC Number 200-708-1 · MDL Number MFCD00064313 Popular Documents:Product Datasheet, Certificate of Analysis, MSDS, See More » |
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Applications Used to select for ampicillin resistance in mutated and transformed cells.
Product Description Ampicillin is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic. It is inactivated by beta-lactamases and for this reason a beta-lactamase inhibitor should be considered when using ampicillin. Against gram-positive bacteria, ampicillin has a similar mode of action as benzylpenicillin; against gram-negative bacteria, it has a similar mode of action as chloramphenicol and tetracyclines. In E. coli it inhibits cell wall synthesis.
Biochem/physiol Actions A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria |
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